| Anna Paquin | ... | Sookie Stackhouse (48 episodes, 2008-2011) |
| Stephen Moyer | ... | Bill Compton (48 episodes, 2008-2011) |
| Sam Trammell | ... | Sam Merlotte (48 episodes, 2008-2011) |
| Ryan Kwanten | ... | Jason Stackhouse (48 episodes, 2008-2011) |
| Rutina Wesley | ... | Tara Thornton (48 episodes, 2008-2011) |
| Chris Bauer | ... | Andy Bellefleur (48 episodes, 2008-2011) |
| Nelsan Ellis | ... | Lafayette Reynolds (48 episodes, 2008-2011) |
| Jim Parrack | ... | Hoyt Fortenberry (48 episodes, 2008-2011) |
| Carrie Preston | ... | Arlene Fowler (48 episodes, 2008-2011) |
| Alexander Skarsgård | ... | Eric Northman (45 episodes, 2008-2011) |
| Todd Lowe | ... | Terry Bellefleur (44 episodes, 2008-2011) |
| Deborah Ann Woll | ... | Jessica Hamby (39 episodes, 2008-2011) |
| William Sanderson | ... | Sheriff Bud Dearborne (36 episodes, 2008-2010) |
| Kristin Bauer | ... | Pam De Beaufort (35 episodes, 2008-2011) |
| Marshall Allman | ... | Tommy Mickens (24 episodes, 2010-2011) |
| Kevin Alejandro | ... | Jesus Velasquez (23 episodes, 2010-2011) |
| Lindsay Pulsipher | ... | Crystal Norris (23 episodes, 2010-2011) |
| Joe Manganiello | ... | Alcide Herveaux (19 episodes, 2010-2011) |
| Adina Porter | ... | Lettie Mae Thornton (18 episodes, 2008-2010) |
| Lauren Bowles | ... | Holly Cleary (16 episodes, 2010-2011) |
| Michelle Forbes | ... | Maryann Forrester (15 episodes, 2008-2009) |
| Jessica Tuck | ... | Nan Flanagan (15 episodes, 2008-2011) |
| Michael Raymond-James | ... | Rene Lenier (14 episodes, 2008-2010) |
| Michael McMillian | ... | Steve Newlin (14 episodes, 2008-2010) |
| John Billingsley | ... | Mike Spencer (14 episodes, 2008-2010) |
| Brit Morgan | ... | Debbie Pelt (14 episodes, 2010-2011) |
| Mehcad Brooks | ... | Eggs (13 episodes, 2008-2009) |
| Mariana Klaveno | ... | Lorena Krasiki (12 episodes, 2008-2010) |
| Dale Raoul | ... | Maxine Fortenberry (12 episodes, 2008-2010) |
| Fiona Shaw | ... | Marnie (12 episodes, 2011) |
| Denis O'Hare | ... | Russell Edgington (11 episodes, 2010) |
| Patricia Bethune | ... | Jane Bodehouse (10 episodes, 2008-2009) |
| Tanya Wright | ... | Deputy Kenya Jones (10 episodes, 2008-2010) |
| Anna Camp | ... | Sarah Newlin (9 episodes, 2009) |
| Adam Leadbeater | ... | Karl (9 episodes, 2008-2009) |
| Tara Buck | ... | Ginger (9 episodes, 2008-2011) |
| Ashley Jones | ... | Daphne Landry (8 episodes, 2009) |
| James Harvey Ward | ... | Felton Norris (8 episodes, 2010-2011) |
| Lois Smith | ... | Adele Stackhouse (7 episodes, 2008) |
| Aisha Hinds | ... | Miss Jeanette (7 episodes, 2008-2009) |
| Grant Bowler | ... | Cooter (7 episodes, 2010) |
| Wes Brown | ... | Luke McDonald (7 episodes, 2009) |
| Theo Alexander | ... | Talbot (7 episodes, 2010) |
| James Frain | ... | Franklin Mott (7 episodes, 2010) |
| J. Smith-Cameron | ... | Melinda Mickens (7 episodes, 2010) |
| Evan Rachel Wood | ... | Sophie-Anne Leclerq (7 episodes, 2009-2010) |
| Janina Gavankar | ... | Luna (6 episodes, 2011) |
| Lizzy Caplan | ... | Amy Burley (6 episodes, 2008) |
| Allan Hyde | ... | Godric (6 episodes, 2009-2010) |
| Gregory Sporleder | ... | Calvin Norris (6 episodes, 2010) |
| Tess Parker | ... | Rosie (6 episodes, 2008-2010) |
| Don Swayze | ... | Gus (6 episodes, 2010) |
| Alec Gray | ... | Coby Fowler (6 episodes, 2008-2009) |
| Melissa Rauch | ... | Summer (6 episodes, 2010) |
| Laurel Weber | ... | Lisa Fowler (6 episodes, 2008-2009) |
| John Rezig | ... | Deputy Kevin Ellis (6 episodes, 2008-2010) |
| Cooper Huckabee | ... | Joe Lee Mickens (6 episodes, 2010-2011) |
| Lynn Collins | ... | Dawn Green (5 episodes, 2008) |
| Lindsey Haun | ... | Hadley Hale (5 episodes, 2009-2010) |
| Valerie Cruz | ... | Isabel (5 episodes, 2009) |
| Natasha Alam | ... | Yvetta (5 episodes, 2010) |
| Stephen Root | ... | Eddie Gauthier (4 episodes, 2008-2009) |
| Raoul Trujillo | ... | Longshadow (4 episodes, 2008) |
| Zeljko Ivanek | ... | Magister (4 episodes, 2008-2010) |
| Patrick Gallagher | ... | Chow (4 episodes, 2008-2009) |
| Graham Shiels | ... | Liam (4 episodes, 2008) |
| John Prosky | ... | David Finch (4 episodes, 2008-2010) |
| Caleb Moody | ... | Royce (4 episodes, 2008-2009) |
| Chris Coy | ... | Barry (4 episodes, 2009) |
| Greg Collins | ... | Gabe (4 episodes, 2009) |
| Courtney Ford | ... | Portia Bellefleur (4 episodes, 2011) |
| Danielle Sapia | ... | Maudette Pickens (3 episodes, 2008) |
| Danielle James | ... | Randi Sue (3 episodes, 2008) |
| Alfre Woodard | ... | Ruby Jean Reynolds (3 episodes, 2010) |
| Andrew Rothenberg | ... | Malcolm (3 episodes, 2008) |
| Aunjanue Ellis | ... | Diane (3 episodes, 2008) |
| Jeremy Denzlinger | ... | Wayne (3 episodes, 2008) |
| Kanin Howell | ... | Chuck (3 episodes, 2008) |
| Lara Pulver | ... | Claudine (3 episodes, 2010) |
| Ed Quinn | ... | Stan (3 episodes, 2009) |
| Stacie Rippy | ... | Cindy Marshall (3 episodes, 2008) |
| Christopher Gartin | ... | Hugo (3 episodes, 2009) |
| John Hillard | ... | Hank (3 episodes, 2009-2010) |
| Avion Baker | ... | Young Tara (3 episodes, 2008-2009) |
| Valorie Hubbard | ... | Random Frenzier (3 episodes, 2009) |
| Grey Damon | ... | Kitch Maynard (3 episodes, 2010) |
| Carlson Young | ... | Tammy (3 episodes, 2010) |
| Simone Bargetze | ... | Frenzy Eye Terra Girl (3 episodes, 2009) |
| Dane DeHaan | ... | Timbo (3 episodes, 2011) |
| Fiona Dourif | ... | Casey (3 episodes, 2011) |
| Brandon Molale | ... | Officer Featherstone (3 episodes, 2011) |
| James Parks | ... | Mack Rattray (2 episodes, 2008) |
| Karina Logue | ... | Denise Rattray (2 episodes, 2008) |
| William Schallert | ... | Mayor Norris (2 episodes, 2008) |
| Michael Bofshever | ... | Orry Dawson (2 episodes, 2008-2009) |
| Melanie MacQueen | ... | Faye Lebvre (2 episodes, 2008) |
| Kevin McHale | ... | Neil Jones (2 episodes, 2008) |
| Judy Prescott | ... | Sue Ann Merlotte (2 episodes, 2008-2009) |
| Cheyenne Wilbur | ... | Uncle Bartlett (2 episodes, 2008) |
| Martin Spanjers | ... | Young Sam (2 episodes, 2008-2009) |
| Price Carson | ... | Mean Looking Frenzier (2 episodes, 2009) |
| Dakin Matthews | ... | Dr. Robideaux (2 episodes, 2010) |
| Missy Doty | ... | Vonetta (2 episodes, 2009) |
| Jack Krizmanich | ... | Ludis (2 episodes, 2009) |
| Lauren Pritchard | ... | Coralee (2 episodes, 2009) |
| Stewart Skelton | ... | Minister (2 episodes, 2008-2010) |
| Preston Jones | ... | Dirk (2 episodes, 2009) |
| Zenali Turner | ... | Young Sookie (2 episodes, 2008) |
| Ailsa Marshall | ... | Desk Clerk (2 episodes, 2009) |
| Gregg Daniel | ... | Reverend Daniels (2 episodes, 2010) |
| Jennifer Hamilton | ... | Dancer #1 (2 episodes, 2009) |
| Sharon Tay | ... | News Anchor / ... (2 episodes, 2008-2009) |
| Labon Hester | ... | Young Jason (2 episodes, 2008) |
| Jeanne Baron | ... | Hostess (2 episodes, 2009-2010) |
| Bryan Becker | ... | Louie (2 episodes, 2010) |
| John Burke | ... | Jerry McCafferty (2 episodes, 2010) |
| Andy Mackenzie | ... | Creepy Biker (2 episodes, 2010) |
| Ronnie Gene Blevins | ... | T-Dub (2 episodes, 2010) |
| Greg Cipes | ... | Bufort Norris (2 episodes, 2010) |
| Kate Luyben | ... | Natalie (2 episodes, 2010) |
| Cheryl Lyone | ... | Vampire Dancer (2 episodes, 2008) |
| Jull Weber | ... | Vampire Dancer (2 episodes, 2008) |
| Kevin Fry | ... | Turk (2 episodes, 2010) |
| Kelly Nienaltowski | ... | Arlene's Friend / ... (2 episodes, 2008) |
| Aaron Jennings Hartnell | ... | Meat Totem Dancer / ... (2 episodes, 2009) |
| Gary Sievers | ... | Hot Shot Hillbilly (2 episodes, 2010-2011) |
| Jobeth Wagner | ... | Fangtasia Vampire (2 episodes, 2010-2011) |
| Poncho Hodges | ... | Officer Trap (2 episodes, 2011) |
| Randy Wayne | ... | Matt (2 episodes, 2011) |
